Can We ‘Wipe Out’ Hospital MRSA?

Three basic principles is all it could take to reduce the incidence of MRSA in hospitals according to new research by Cardiff University.

Disinfectants are routinely used on hard surfaces in hospitals to kill bacteria, with antimicrobial containing wipes increasingly being employed for this purpose. Antimicrobial wipes were first introduced in 2005 in hospitals in Wales.  

A study by the University’s Welsh School of Pharmacy looked into the ability of antimicrobial-surface wipes to remove, kill and prevent the spread of such infections as MRSA. They found that current protocols utilized by hospital staff have the potential to spread pathogens after only the first use of a wipe, particularly due to the ineffectiveness of wipes to actually kill bacteria.

The team, led by microbiologist Dr. Jean-Yves Maillard is now calling for a ‘one wipe – one application – per surface’ approach to infection control in healthcare environments.

The research involved a surveillance program observing hospital staff using surface wipes to decontaminate surfaces near patients, such as bed rails, and other surfaces commonly touched by staff and patients, such as monitors, tables and key pads. It was found that the wipes were being applied to the same surface several times and used on consecutive surfaces before being discarded.

These actions were then replicated in the lab alongside a three-step system, developed by the research team to test the ability of several commercially available wipes to disinfect surfaces contaminated with strains of Staphylococcus aureus, including MRSA and MSSA (Methicillin-Sensitive Staphylococcus aureus). The system tested the removal of pathogens, the transmission of them, and the anti-microbial properties of wipes.

The study revealed that although some wipes can remove higher numbers of bacteria from surfaces than others, the wipes tested were unable to kill the bacteria removed.  As a result, high numbers of bacteria were transferred to other surfaces when reused.

Dr. Gareth Williams, microbiologist at the Welsh School of Pharmacy, said: "Claims of effectiveness, such as ‘kills MRSA’, are ubiquitous on the packaging of antimicrobial-containing wipes.  Methods currently available to test the performance of these products may be inappropriate since they do not assess the ability of wipes to actually disinfect surfaces. We have developed a simple, rapid, robust and reproducible method which will help identify best practice in the use of the wipes.

"Our surveillance study in its own right has been highly revealing in that it has highlighted the risks associated with the way decontamination products are currently being deployed in Welsh hospitals and the need for routine observation as well as proper training in the use of these wipes in reducing risks of infection to patients.

"On the whole, wipes can be effective in removing, killing and preventing the transfer of pathogens such as MRSA but only if used in the right way.  We found that the most effective way to prevent the risk of MRSA spread in hospital wards is to ensure the wipe is used only once on one surface."

It is anticipated the research will promote a UK and worldwide routine surveillance program examining the effectiveness of disinfectants used in hospitals, and if applied will help assure the public that control measures are being carefully scrutinised, and would undoubtedly be beneficial.

Dr. Gareth Williams presented the research findings at the American Society of Microbiology’s 108th General Meeting in Boston, Massachusetts on 3rd June 2008.

The study has been supported by a grant from the Wales Office of Research and Development for Health and Social Care (WORD).

About Cardiff University

Cardiff University is recognized in independent government assessments as one of Britain’s leading teaching and research universities. It is also ranked as one of the world’s top 100 universities by the Times Higher Education Supplement (THES).

2008 marks the 125th anniversary of Cardiff University having been founded by Royal Charter in 1883.  Today the University combines impressive modern facilities and a dynamic approach to teaching and research. The University’s breadth of expertise in research and research-led teaching encompasses: the humanities; the natural, physical, health, life and social sciences; engineering and technology; preparation for a wide range of professions; and a longstanding commitment to lifelong learning.  Cardiff is a member of the Russell Group of the UK’s leading research universities. Visit the University Web site at:

Welsh School of Pharmacy

The Welsh School of Pharmacy, which was founded in 1919, is the only school of pharmacy in Wales.  In independent government assessments of university teaching and research, the School was awarded the double accolade of the top rating, "Excellent" for teaching, and the top rating "Grade 5" for research.

The School’s collaboration with institutions and pharmaceutical companies in Europe and the USA emphasizes the School’s international reputation for research. The School has four research groups looking at drug delivery; drug usage; design and synthesis of drugs; and molecular and cellular basis of drug action.

The School also oversees the activities of the Welsh Centre for Postgraduate Pharmaceutical Education, which is concerned with continuing education for all of Wales’ 2,100 pharmacists.

For more media information contact:

Dr. Jean-Yves Maillard
E: [email protected]

Dr. Gareth Williams
Welsh School of Pharmacy
Cardiff University
T: 07813029269
E: [email protected]

Lowri Jones

Public Relations and Communications
Cardiff University
T: 02920 870 995
E: [email protected]